About the Author
|Edited by Mary V. Solanto, Associate Professor of Psychiatry and Director of the Attention Deficit Disorder Center, The Mount Sinai School of Medicine.
Amy F. T. Arnsten, Associate Professor, Section on Neurobiology, Yale University School of Medicine.
F. Xavier Castellanos, Chief, Attention Deficit Hyperactivity Disorder Research Unit, Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health
Stimulant drugs are widely used in the treatment of ADHD in children and adults, yet their mechanism of action have been poorly understood. This volume is the first to integrate advances in the basic and clinical neurosciences in order to shed new light on this important question. The chapter topics span basic research into the neuroanatomy, neurophysiology and neuropsychology of catecholamines, animal models of ADHD, and clinical studies of neuroimaging, genetics, pharmacokinetics and pharmacodynamics, and the cognitive pharmacology of stimulants. The result is a careful, comprehensive, and insightful synthesis by a group of well-known scientists that significantly advances our understanding of stimulant effects and charts a course for future research.
pull together evidence from the basic and clinical neurosciences that may ultimately help explain how stimulant drugs act to reduce the behavioral and cognitive symptoms associated with attention-deficit-hyperactivity disorder (ADHD)."
Part I: Phenomenology
- Attention-Deficit/Hyperactivity Disorder: Clinical Features, Mary V. Solanto
- Clinical Effects of Stimulant Medication in ADHD, Lawrence L. Greenhill
Part II: Basic Neuroscience
Introduction, Amy F.T. Arnsten
Part III: Clinical Neuroscience
- The Catecholamine Innervation of Primate Cerebral Cortex, David A. Lewis
- Stimulant Effects on Striatal and Cortical Dopamine Systems Involved in Reward-Related Behavior and Impulsivity, Jane R. Taylor & J. David Jentsch
- Psychostimulant Actions on Dopamine and Limbic System Function: Relevance to the Pathophysiology and Treatment of ADHD, Anthony A. Grace
- Arousal- and Attention-Related Actions of the Locus Coeruleus-Noradrenergic System: Potential Target in the Therapeutic Actions of Amphetamine-Like Stimulants, Craig W. Berridge
- Dopaminergic and Noradrenergic Influences on Cognitive Functions Mediated by Prefrontal Cortex, Amy F.T. Arnsten
- A Review of Rodent Models of ADHD, Sherry A. Ferguson
- The Spontaneously Hypertensive Rat as a Model of ADHD, Terje Sagvolden
Introduction, Mary V. Solanto
Part IV: Integration
- Neuroimaging Studies of ADHD, F. Xavier Castellanos
- Pharmacokinetic and Pharmacodynamic Properties of methylphenidate in Humans, James Swanson & Nora Volkow
- The Cognitive Pharmacology of Stimulants in Children with ADHD, Colin B. Denney and Mark D. Rapport
- Comparative Psychopharmacology of Methylphenidate and Related Drugs in Human Volunteers, Patients with ADHD, and Experimental Animals, Mitul A. Mehta, Barbara J. Sahakian, and Trevor W. Robbins
- Comparing the Effects of Stimulant and Non-Stimulant Agents on Catecholamine Function: Implications fot Theories of ADHD, Steven R. Pliszka
Appendix:. The Behavior of Children Receiving Benzedrine, Charles Bradley
- The Neuroscience of Stimulant Drug Action in ADHD, Mary V. Solanto, Amy F.T. Arnsten, and F. Xavier Castellanos